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KPV is a tripeptide fragment of alpha-MSH studied for its anti-inflammatory properties and gut health research applications.
β οΈ For research purposes only. Not for human consumption. By purchasing you confirm you are a qualified researcher.
KPV Overview
KPV is a small tripeptide derived from the C-terminus of Ξ±-MSH that retains signaling activity while lacking melanotropic effects. Through PepT1-mediated uptake in epithelial and macrophage models, KPV directly accesses intracellular compartments where it modulates NF-ΞΊB signaling and reduces expression of key cytokines including TNF-Ξ±, IL-1Ξ², IL-6, and IL-8. Research models examine KPV's effects on cytokine signaling cascades, epithelial barrier dynamics through tight junction protein regulation, mucosal modeling in experimental systems, and antimicrobial properties in laboratory settings.Dalmasso et al. (2008). Brzoska et al. (2008).
KPV Structure
CAS #: 67727-97-3
Molecular Formula: CββHββNβOβ
Molecular Weight: 358.44 g/mol
PubChem ID: 67727
Research Findings
KPV has been extensively studied in cytokine signaling research, with investigations focusing on NF-ΞΊB pathway modulation, epithelial signaling models, barrier dynamics, and immune modulation in various experimental systems. Studies examine both its unique transporter-mediated delivery and potent cytokine-modulating mechanisms.
Key Areas of Research:
- Cytokine: NF-ΞΊB, MAPK, suppression
- Epithelial: Mucosal signaling, modeling
- Barrier: Tight junction, permeability, integrity
- Immune: Peptide-receptor, macrophage, T-cell
References
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