Quantity
MOTS-c is a mitochondria-derived peptide studied for metabolic regulation, exercise performance, and longevity research.
⚠️ For research purposes only. Not for human consumption. By purchasing you confirm you are a qualified researcher.
MOTS-c Overview
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino-acid mitochondria-derived peptide encoded within the 12S ribosomal RNA gene of the mitochondrial genome. First described in 2015, it represents a newly characterized class of mitochondria-derived peptides (MDPs) that function as inter-organelle signaling molecules. MOTS-c has been studied in preclinical models for its role in metabolic regulation, including effects on insulin sensitivity, fatty acid oxidation, and AMPK activation. Research has also explored its potential relevance to aging-associated metabolic changes.
MOTS-c Structure
CAS #: 1627580-64-6
Molecular Formula: C₁₄₉H₂₆₀N₄₆O₄₆S₂
Molecular Weight: 2171.5 g/mol
PubChem ID: 91808068
Research Findings
MOTS-c has been studied in mitochondrial, molecular, and systemic models, with research highlighting its role in mitochondrial function, AMPK pathway activation, and signaling dynamics. Studies also report activity in substrate utilization, downstream markers, and molecular stress responses in preclinical settings.
Key Areas of Research:
- Mitochondrial: AMPK, signaling, pathway dynamicsMolecular: Mitochondrial function, stress response, remodelingSystemic: Signaling, resilience, viabilityTogether, these findings suggest broad experimental potential for MOTS-c across mitochondrial, molecular, and systemic pathways. By engaging mitochondrial biology and modulating AMPK and stress response pathways, MOTS-c provides a versatile platform for research into pathway characterization, molecular dynamics, and systemic resilience in laboratory settings.Lee C. et al., 2015
References
Same Category
