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PT-141
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PT-141 (Bremelanotide) is a melanocortin peptide studied for libido and sexual function in research settings.

⚠️ For research purposes only. Not for human consumption. By purchasing you confirm you are a qualified researcher.

PT-141 Overview

PT-141, also known as Bremelanotide, is a synthetic peptide analog of Ξ±-melanocyte-stimulating hormone (Ξ±-MSH). It is studied in laboratory and preclinical models for its ability to activate melanocortin receptors (MC3R and MC4R), which are involved in neuroendocrine signaling, energy regulation, and vascular pathways.Dorr R.T. et al. (1996).

PT-141 Structure

PT-141 molecular structure

CAS #: 189691-06-3

Molecular Formula: Cβ‚…β‚€Hβ‚†β‚ˆN₁₄O₁₀

Molecular Weight: 1025.2 g/mol

PubChem ID: 6918280

Research Findings

PT-141 has been studied in neurological, endocrine, and systemic models, with research highlighting its activity in target receptor pathways, neuroendocrine signaling, and systemic dynamics. Studies also report effects on central nervous system activity, endocrine modulation, and vascular responses in preclinical settings.

Key Areas of Research:

  • Neurological: CNS activity, signaling, pathwaysEndocrine: Modulation, signaling dynamicsSystemic: Vascular responses, viability, resilienceTogether, these findings suggest experimental potential for PT-141 across neurological, endocrine, and systemic pathways. By engaging target receptor pathways and influencing neuroendocrine activity, PT-141 provides a versatile platform for research into signaling biology, systemic dynamics, and central pathway characterization in laboratory settings.Shadiack A.M. et al., 2004

References

Dorr R.T. et al. (1996). Pharmacology and receptor activity of melanocortin peptides in preclinical models. J Invest Dermatol, 106(6):1125–1131.Shadiack A.M. et al. (2002). Melanocortin receptor agonists and their role in neuroendocrine signaling. J Pharmacol Exp Ther, 301(1):349–355.King S.H. et al. (2005). Receptor pharmacology of PT-141 at MC3R and MC4R sites. Peptides, 26(6):1068–1073. 

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