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TB-500
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TB-500 (Thymosin Beta-4) is a naturally occurring peptide studied for wound healing, tissue repair, and anti-inflammatory properties.

⚠️ For research purposes only. Not for human consumption. By purchasing you confirm you are a qualified researcher.

TB-500 Overview

TB-500 is a synthetic peptide fragment derived from thymosin beta-4, a naturally occurring protein studied for its role in molecular signaling and pathway dynamics. Research has focused on its potential influence on matrix remodeling, angiogenesis, and molecular migration in preclinical and laboratory models. TB-500 is of particular interest in investigations involving connective tissue, structural dynamics, and extracellular matrix pathways.Goldstein A.L. et al. (2005). 

TB-500 Structure

TB-500 molecular structure

CAS #: 77591-33-4

Molecular Formula: C₂₁₂H₃₅₀N₅₆Oβ‚‡β‚ˆS

Molecular Weight: 4963.5 g/mol

PubChem ID: 16132321

Research Findings

TB-500 has been studied in structural, vascular, epithelial, and systemic models, with research exploring its roles in collagen organization, extracellular matrix remodeling, angiogenesis, molecular migration, and pathway activity in preclinical settings.

Key Areas of Research:

  • Structural: Collagen, matrix, tendon/ligamentVascular: Angiogenesis, nitric oxide, remodelingEpithelial: Migration, signaling, matrixSystemic: Signaling, viability, pathway dynamicsTogether, these findings suggest broad experimental utility for TB-500 across multiple biological pathways. By engaging structural and vascular processes and supporting epithelial and systemic responses, TB-500 provides a versatile platform for investigating molecular remodeling, pathway dynamics, and resilience in laboratory settings.Hsieh M.-J. et al., 2017

References

Goldstein A.L. et al. (2005). Thymosin beta-4 and tissue regeneration: potential mechanisms of action. Ann N Y Acad Sci.Goldstein A.L., Hannappel E. et al. (2012). Thymosin beta-4: a multifunctional regenerative peptide. Expert Opin Biol Ther, 12(1):37–51.Malinda K.M. et al. (1999). Thymosin beta-4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J, 13(6):693–701.

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